Association of Cardiometabolic Multimorbidity With Mortality.
Identifieur interne : 003136 ( Main/Exploration ); précédent : 003135; suivant : 003137Association of Cardiometabolic Multimorbidity With Mortality.
Auteurs : Emanuele Di Angelantonio [Royaume-Uni] ; Stephen Kaptoge [Royaume-Uni] ; David Wormser [Royaume-Uni] ; Peter Willeit [Royaume-Uni] ; Adam S. Butterworth [Royaume-Uni] ; Narinder Bansal [Royaume-Uni] ; Linda M. O'Keeffe [Royaume-Uni] ; Pei Gao [Royaume-Uni] ; Angela M. Wood [Royaume-Uni] ; Stephen Burgess [Royaume-Uni] ; Daniel F. Freitag [Royaume-Uni] ; Lisa Pennells [Royaume-Uni] ; Sanne A. Peters [Pays-Bas] ; Carole L. Hart [Royaume-Uni] ; Lise Lund H Heim [Norvège] ; Richard F. Gillum [États-Unis] ; B Rge G. Nordestgaard [Danemark] ; Bruce M. Psaty [États-Unis] ; Bu B. Yeap ; Matthew W. Knuiman ; Paul J. Nietert ; Jussi Kauhanen ; Jukka T. Salonen [Finlande] ; Lewis H. Kuller [États-Unis] ; Leon A. Simons [Australie] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Elizabeth Barrett-Connor ; Randi Selmer [Norvège] ; Carlos J. Crespo [États-Unis] ; Beatriz Rodriguez ; W M Monique Verschuren [Pays-Bas] ; Veikko Salomaa [Finlande] ; Kurt Sv Rdsudd [Suède] ; Pim Van Der Harst [Pays-Bas] ; Cecilia Björkelund [Suède] ; Lars Wilhelmsen [Suède] ; Robert B. Wallace [États-Unis] ; Hermann Brenner [Allemagne] ; Philippe Amouyel [France] ; Elizabeth L M. Barr [Australie] ; Hiroyasu Iso [Japon] ; Altan Onat [Turquie] ; Maurizio Trevisan [États-Unis] ; Ralph B. D'Agostino [États-Unis] ; Cyrus Cooper [Royaume-Uni] ; Maryam Kavousi [Pays-Bas] ; Lennart Welin [Suède] ; Ronan Roussel [France] ; Frank B. Hu [États-Unis] ; Shinichi Sato [Japon] ; Karina W. Davidson [États-Unis] ; Barbara V. Howard [États-Unis] ; Maarten J G. Leening [Pays-Bas] ; Maarten Leening [Pays-Bas] ; Annika Rosengren [Suède] ; Marcus Dörr [Allemagne] ; Dorly J H. Deeg [Pays-Bas] ; Stefan Kiechl [Autriche] ; Coen D A. Stehouwer [Pays-Bas] ; Aulikki Nissinen [Finlande] ; Simona Giampaoli [Italie] ; Chiara Donfrancesco [Italie] ; Daan Kromhout [Pays-Bas] ; Jackie F. Price [Royaume-Uni] ; Annette Peters [Allemagne] ; Tom W. Meade [Royaume-Uni] ; Edoardo Casiglia [Italie] ; Debbie A. Lawlor [Royaume-Uni] ; John Gallacher [Royaume-Uni] ; Dorothea Nagel [Allemagne] ; Oscar H. Franco [Pays-Bas] ; Gerd Assmann [Allemagne] ; Gilles R. Dagenais [Canada] ; J Wouter Jukema [Pays-Bas] ; Johan Sundström [Suède] ; Mark Woodward [Australie] ; Eric J. Brunner [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Nicholas J. Wareham [Royaume-Uni] ; Eric A. Whitsel ; Inger Nj Lstad [Norvège] ; Bo Hedblad [Suède] ; Sylvia Wassertheil-Smoller [États-Unis] ; Gunnar Engström [Suède] ; Wayne D. Rosamond ; Elizabeth Selvin [États-Unis] ; Naveed Sattar [Royaume-Uni] ; Simon G. Thompson [Royaume-Uni] ; John Danesh [Royaume-Uni]Source :
- JAMA [ 1538-3598 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- épidémiologie : Accident vasculaire cérébral, Diabète, Infarctus du myocarde.
- Adulte, Adulte d'âge moyen, Comorbidité, Espérance de vie, Facteurs de risque, Femelle, Humains, Mortalité, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Diabetes Mellitus, Myocardial Infarction, Stroke.
- Adult, Aged, Comorbidity, Female, Humans, Life Expectancy, Male, Middle Aged, Mortality, Risk Factors.
Abstract
The prevalence of cardiometabolic multimorbidity is increasing.
DOI: 10.1001/jama.2015.7008
PubMed: 26151266
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, Finlande, France, Italie, Japon, Norvège, Pays-Bas, Royaume-Uni, Suède, Turquie, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, District de Columbia, District de Haute-Bavière, District de Karlsruhe, East Middle Sweden, Groningue (province), Gueldre (province), Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Hovedstaden, Iowa, Latium, Maryland, Massachusetts, Nord-Pas-de-Calais, Nouvelle-Galles du Sud, Oregon, Pennsylvanie, Svealand, Utrecht (province), Washington (État), Écosse, État de New York, Île-de-France, Østlandet
- Amsterdam, Copenhague, Groningue, Heidelberg, Iowa City, Leyde, Lille, Munich, Oslo, Paris, Rome, Rotterdam, Seattle, Sydney, Uppsala, Utrecht, Wageningue
- Université d'Uppsala, Université de Sydney, Université de Wageningue, Université de Washington, Université de l'Iowa
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Le document en format XML
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Simons</name><affiliation wicri:level="1"><nlm:affiliation>University of New South Wales, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. 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Wallace</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Iowa, Iowa City.</nlm:affiliation><orgName type="university">Université de l'Iowa</orgName><country>États-Unis</country><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Barr, Elizabeth L M" sort="Barr, Elizabeth L M" uniqKey="Barr E" first="Elizabeth L M" last="Barr">Elizabeth L M. Barr</name><affiliation wicri:level="1"><nlm:affiliation>Baker IDI Heart and Diabetes Institute, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Iso, Hiroyasu" sort="Iso, Hiroyasu" uniqKey="Iso H" first="Hiroyasu" last="Iso">Hiroyasu Iso</name><affiliation wicri:level="1"><nlm:affiliation>Osaka University, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka University, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Onat, Altan" sort="Onat, Altan" uniqKey="Onat A" first="Altan" last="Onat">Altan Onat</name><affiliation wicri:level="1"><nlm:affiliation>Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Trevisan, Maurizio" sort="Trevisan, Maurizio" uniqKey="Trevisan M" first="Maurizio" last="Trevisan">Maurizio Trevisan</name><affiliation wicri:level="2"><nlm:affiliation>City College of New York, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>City College of New York, New York</wicri:cityArea></affiliation></author><author><name sortKey="D Agostino, Ralph B" sort="D Agostino, Ralph B" uniqKey="D Agostino R" first="Ralph B" last="D'Agostino">Ralph B. D'Agostino</name><affiliation wicri:level="2"><nlm:affiliation>Boston University, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="2"><nlm:affiliation>University of Southampton, Southampton, England32University of Oxford, Oxford, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Southampton, Southampton, England32University of Oxford, Oxford</wicri:cityArea></affiliation></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Welin, Lennart" sort="Welin, Lennart" uniqKey="Welin L" first="Lennart" last="Welin">Lennart Welin</name><affiliation wicri:level="1"><nlm:affiliation>Lidköping Hospital, Lidköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lidköping Hospital, Lidköping</wicri:regionArea><wicri:noRegion>Lidköping</wicri:noRegion></affiliation></author><author><name sortKey="Roussel, Ronan" sort="Roussel, Ronan" uniqKey="Roussel R" first="Ronan" last="Roussel">Ronan Roussel</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre de Recherche des Cordeliers, Paris, France36Université Paris Diderot, Paris, France37Diabétologie, AP-HP, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre de Recherche des Cordeliers, Paris, France36Université Paris Diderot, Paris, France37Diabétologie, AP-HP, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="2"><nlm:affiliation>Harvard School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sato, Shinichi" sort="Sato, Shinichi" uniqKey="Sato S" first="Shinichi" last="Sato">Shinichi Sato</name><affiliation wicri:level="1"><nlm:affiliation>Osaka Medical Center for Health Science and Promotion/Chiba Prefectural Institute of Public Health, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka Medical Center for Health Science and Promotion/Chiba Prefectural Institute of Public Health, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Davidson, Karina W" sort="Davidson, Karina W" uniqKey="Davidson K" first="Karina W" last="Davidson">Karina W. Davidson</name><affiliation wicri:level="2"><nlm:affiliation>Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Howard, Barbara V" sort="Howard, Barbara V" uniqKey="Howard B" first="Barbara V" last="Howard">Barbara V. Howard</name><affiliation wicri:level="2"><nlm:affiliation>MedStar Health Research Institute, Hyattsville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>MedStar Health Research Institute, Hyattsville</wicri:cityArea></affiliation></author><author><name sortKey="Leening, Maarten J G" sort="Leening, Maarten J G" uniqKey="Leening M" first="Maarten J G" last="Leening">Maarten J G. Leening</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Leening, Maarten" sort="Leening, Maarten" uniqKey="Leening M" first="Maarten" last="Leening">Maarten Leening</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rosengren, Annika" sort="Rosengren, Annika" uniqKey="Rosengren A" first="Annika" last="Rosengren">Annika Rosengren</name><affiliation wicri:level="1"><nlm:affiliation>Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Greifswald, Greifswald, Germany44DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Greifswald, Greifswald, Germany44DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Deeg, Dorly J H" sort="Deeg, Dorly J H" uniqKey="Deeg D" first="Dorly J H" last="Deeg">Dorly J H. Deeg</name><affiliation wicri:level="3"><nlm:affiliation>Vrije Universiteit Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Vrije Universiteit Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Stehouwer, Coen D A" sort="Stehouwer, Coen D A" uniqKey="Stehouwer C" first="Coen D A" last="Stehouwer">Coen D A. Stehouwer</name><affiliation wicri:level="1"><nlm:affiliation>Maastricht University Medical Centre, Maastricht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Giampaoli, Simona" sort="Giampaoli, Simona" uniqKey="Giampaoli S" first="Simona" last="Giampaoli">Simona Giampaoli</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Donfrancesco, Chiara" sort="Donfrancesco, Chiara" uniqKey="Donfrancesco C" first="Chiara" last="Donfrancesco">Chiara Donfrancesco</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Kromhout, Daan" sort="Kromhout, Daan" uniqKey="Kromhout D" first="Daan" last="Kromhout">Daan Kromhout</name><affiliation wicri:level="4"><nlm:affiliation>Wageningen University, Wageningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation wicri:level="2"><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany52German Research Center for Cardiovascular Research (DZHK eV), Partner-Site Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany52German Research Center for Cardiovascular Research (DZHK eV), Partner-Site Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Meade, Tom W" sort="Meade, Tom W" uniqKey="Meade T" first="Tom W" last="Meade">Tom W. Meade</name><affiliation wicri:level="2"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>London School of Hygiene and Tropical Medicine, London</wicri:cityArea></affiliation></author><author><name sortKey="Casiglia, Edoardo" sort="Casiglia, Edoardo" uniqKey="Casiglia E" first="Edoardo" last="Casiglia">Edoardo Casiglia</name><affiliation wicri:level="1"><nlm:affiliation>University of Padova, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Padova, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="2"><nlm:affiliation>University of Bristol, Bristol, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Bristol, Bristol</wicri:cityArea></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="2"><nlm:affiliation>Cardiff University, Cardiff, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Cardiff University, Cardiff</wicri:cityArea></affiliation></author><author><name sortKey="Nagel, Dorothea" sort="Nagel, Dorothea" uniqKey="Nagel D" first="Dorothea" last="Nagel">Dorothea Nagel</name><affiliation wicri:level="3"><nlm:affiliation>Klinikum der Universität München LMU, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum der Universität München LMU, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Assmann, Gerd" sort="Assmann, Gerd" uniqKey="Assmann G" first="Gerd" last="Assmann">Gerd Assmann</name><affiliation wicri:level="1"><nlm:affiliation>Assmann-Stiftung für Prävention, Munster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Assmann-Stiftung für Prävention, Munster</wicri:regionArea><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion></affiliation></author><author><name sortKey="Dagenais, Gilles R" sort="Dagenais, Gilles R" uniqKey="Dagenais G" first="Gilles R" last="Dagenais">Gilles R. Dagenais</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et Pneumologie de Québec, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et Pneumologie de Québec, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation wicri:level="4"><nlm:affiliation>Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name><affiliation wicri:level="2"><nlm:affiliation>University College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="2"><nlm:affiliation>Medical Research Council Epidemiology Unit, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Medical Research Council Epidemiology Unit, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Whitsel, Eric A" sort="Whitsel, Eric A" uniqKey="Whitsel E" first="Eric A" last="Whitsel">Eric A. Whitsel</name><affiliation><nlm:affiliation>Department of Medicine, University of North Carolina, Chapel Hill65Department of Epidemiology, University of North Carolina, Chapel Hill.</nlm:affiliation><wicri:noCountry code="subField">Chapel Hill</wicri:noCountry></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation wicri:level="1"><nlm:affiliation>University of Tromsø, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Tromsø, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation wicri:level="1"><nlm:affiliation>Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name><affiliation wicri:level="2"><nlm:affiliation>Albert Einstein College of Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Albert Einstein College of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation wicri:level="1"><nlm:affiliation>Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Rosamond, Wayne D" sort="Rosamond, Wayne D" uniqKey="Rosamond W" first="Wayne D" last="Rosamond">Wayne D. Rosamond</name><affiliation><nlm:affiliation>University of North Carolina, Chapel Hill.</nlm:affiliation><wicri:noCountry code="subField">Chapel Hill</wicri:noCountry></affiliation></author><author><name sortKey="Selvin, Elizabeth" sort="Selvin, Elizabeth" uniqKey="Selvin E" first="Elizabeth" last="Selvin">Elizabeth Selvin</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="2"><nlm:affiliation>University of Glasgow, Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>University of Glasgow, Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Simon G" sort="Thompson, Simon G" uniqKey="Thompson S" first="Simon G" last="Thompson">Simon G. Thompson</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26151266</idno><idno type="pmid">26151266</idno><idno type="doi">10.1001/jama.2015.7008</idno><idno type="wicri:Area/PubMed/Corpus">002B46</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B46</idno><idno type="wicri:Area/PubMed/Curation">002A74</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A74</idno><idno type="wicri:Area/PubMed/Checkpoint">002A74</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A74</idno><idno type="wicri:Area/Ncbi/Merge">002812</idno><idno type="wicri:Area/Ncbi/Curation">002812</idno><idno type="wicri:Area/Ncbi/Checkpoint">002812</idno><idno type="wicri:Area/Main/Merge">003137</idno><idno type="wicri:Area/Main/Curation">003136</idno><idno type="wicri:Area/Main/Exploration">003136</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of Cardiometabolic Multimorbidity With Mortality.</title><author><name sortKey="Di Angelantonio, Emanuele" sort="Di Angelantonio, Emanuele" uniqKey="Di Angelantonio E" first="Emanuele" last="Di Angelantonio">Emanuele Di Angelantonio</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Kaptoge, Stephen" sort="Kaptoge, Stephen" uniqKey="Kaptoge S" first="Stephen" last="Kaptoge">Stephen Kaptoge</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Wormser, David" sort="Wormser, David" uniqKey="Wormser D" first="David" last="Wormser">David Wormser</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Willeit, Peter" sort="Willeit, Peter" uniqKey="Willeit P" first="Peter" last="Willeit">Peter Willeit</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S" last="Butterworth">Adam S. Butterworth</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Bansal, Narinder" sort="Bansal, Narinder" uniqKey="Bansal N" first="Narinder" last="Bansal">Narinder Bansal</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="O Keeffe, Linda M" sort="O Keeffe, Linda M" uniqKey="O Keeffe L" first="Linda M" last="O'Keeffe">Linda M. O'Keeffe</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Pei" sort="Gao, Pei" uniqKey="Gao P" first="Pei" last="Gao">Pei Gao</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Wood, Angela M" sort="Wood, Angela M" uniqKey="Wood A" first="Angela M" last="Wood">Angela M. Wood</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Burgess, Stephen" sort="Burgess, Stephen" uniqKey="Burgess S" first="Stephen" last="Burgess">Stephen Burgess</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Freitag, Daniel F" sort="Freitag, Daniel F" uniqKey="Freitag D" first="Daniel F" last="Freitag">Daniel F. Freitag</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Pennells, Lisa" sort="Pennells, Lisa" uniqKey="Pennells L" first="Lisa" last="Pennells">Lisa Pennells</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Sanne A" sort="Peters, Sanne A" uniqKey="Peters S" first="Sanne A" last="Peters">Sanne A. Peters</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Hart, Carole L" sort="Hart, Carole L" uniqKey="Hart C" first="Carole L" last="Hart">Carole L. Hart</name><affiliation wicri:level="2"><nlm:affiliation>University of Glasgow, Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>University of Glasgow, Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="H Heim, Lise Lund" sort="H Heim, Lise Lund" uniqKey="H Heim L" first="Lise Lund" last="H Heim">Lise Lund H Heim</name><affiliation wicri:level="3"><nlm:affiliation>University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gillum, Richard F" sort="Gillum, Richard F" uniqKey="Gillum R" first="Richard F" last="Gillum">Richard F. Gillum</name><affiliation wicri:level="2"><nlm:affiliation>Howard University College of Medicine, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Howard University College of Medicine, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation wicri:level="3"><nlm:affiliation>Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen University Hospital, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:affiliation>University of Washington, Seattle.</nlm:affiliation><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Yeap, Bu B" sort="Yeap, Bu B" uniqKey="Yeap B" first="Bu B" last="Yeap">Bu B. Yeap</name><affiliation><nlm:affiliation>University of Western Australia, Perth.</nlm:affiliation><wicri:noCountry code="subField">Perth</wicri:noCountry></affiliation></author><author><name sortKey="Knuiman, Matthew W" sort="Knuiman, Matthew W" uniqKey="Knuiman M" first="Matthew W" last="Knuiman">Matthew W. Knuiman</name><affiliation><nlm:affiliation>University of Western Australia, Perth.</nlm:affiliation><wicri:noCountry code="subField">Perth</wicri:noCountry></affiliation></author><author><name sortKey="Nietert, Paul J" sort="Nietert, Paul J" uniqKey="Nietert P" first="Paul J" last="Nietert">Paul J. Nietert</name><affiliation><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name><affiliation><nlm:affiliation>University of Eastern Finland, Kuopio.</nlm:affiliation><wicri:noCountry code="subField">Kuopio</wicri:noCountry></affiliation></author><author><name sortKey="Salonen, Jukka T" sort="Salonen, Jukka T" uniqKey="Salonen J" first="Jukka T" last="Salonen">Jukka T. Salonen</name><affiliation wicri:level="1"><nlm:affiliation>Metabolic Analytical Services Inc, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Metabolic Analytical Services Inc, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Simons, Leon A" sort="Simons, Leon A" uniqKey="Simons L" first="Leon A" last="Simons">Leon A. Simons</name><affiliation wicri:level="1"><nlm:affiliation>University of New South Wales, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><affiliation><nlm:affiliation>University of California-San Diego, La Jolla.</nlm:affiliation><wicri:noCountry code="subField">La Jolla</wicri:noCountry></affiliation></author><author><name sortKey="Selmer, Randi" sort="Selmer, Randi" uniqKey="Selmer R" first="Randi" last="Selmer">Randi Selmer</name><affiliation wicri:level="3"><nlm:affiliation>Norwegian Institute of Public Health, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian Institute of Public Health, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Crespo, Carlos J" sort="Crespo, Carlos J" uniqKey="Crespo C" first="Carlos J" last="Crespo">Carlos J. Crespo</name><affiliation wicri:level="2"><nlm:affiliation>Portland State University, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Portland State University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Rodriguez, Beatriz" sort="Rodriguez, Beatriz" uniqKey="Rodriguez B" first="Beatriz" last="Rodriguez">Beatriz Rodriguez</name><affiliation><nlm:affiliation>University of Hawaii, Honolulu.</nlm:affiliation><wicri:noCountry code="subField">Honolulu</wicri:noCountry></affiliation></author><author><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Public Health and the Environment, Bilthoven, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Sv Rdsudd, Kurt" sort="Sv Rdsudd, Kurt" uniqKey="Sv Rdsudd K" first="Kurt" last="Sv Rdsudd">Kurt Sv Rdsudd</name><affiliation wicri:level="4"><nlm:affiliation>Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Bjorkelund, Cecilia" sort="Bjorkelund, Cecilia" uniqKey="Bjorkelund C" first="Cecilia" last="Björkelund">Cecilia Björkelund</name><affiliation wicri:level="1"><nlm:affiliation>University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Wilhelmsen, Lars" sort="Wilhelmsen, Lars" uniqKey="Wilhelmsen L" first="Lars" last="Wilhelmsen">Lars Wilhelmsen</name><affiliation wicri:level="1"><nlm:affiliation>University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Wallace, Robert B" sort="Wallace, Robert B" uniqKey="Wallace R" first="Robert B" last="Wallace">Robert B. Wallace</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Iowa, Iowa City.</nlm:affiliation><orgName type="university">Université de l'Iowa</orgName><country>États-Unis</country><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Barr, Elizabeth L M" sort="Barr, Elizabeth L M" uniqKey="Barr E" first="Elizabeth L M" last="Barr">Elizabeth L M. Barr</name><affiliation wicri:level="1"><nlm:affiliation>Baker IDI Heart and Diabetes Institute, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Baker IDI Heart and Diabetes Institute, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Iso, Hiroyasu" sort="Iso, Hiroyasu" uniqKey="Iso H" first="Hiroyasu" last="Iso">Hiroyasu Iso</name><affiliation wicri:level="1"><nlm:affiliation>Osaka University, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka University, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Onat, Altan" sort="Onat, Altan" uniqKey="Onat A" first="Altan" last="Onat">Altan Onat</name><affiliation wicri:level="1"><nlm:affiliation>Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Trevisan, Maurizio" sort="Trevisan, Maurizio" uniqKey="Trevisan M" first="Maurizio" last="Trevisan">Maurizio Trevisan</name><affiliation wicri:level="2"><nlm:affiliation>City College of New York, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>City College of New York, New York</wicri:cityArea></affiliation></author><author><name sortKey="D Agostino, Ralph B" sort="D Agostino, Ralph B" uniqKey="D Agostino R" first="Ralph B" last="D'Agostino">Ralph B. D'Agostino</name><affiliation wicri:level="2"><nlm:affiliation>Boston University, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><affiliation wicri:level="2"><nlm:affiliation>University of Southampton, Southampton, England32University of Oxford, Oxford, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Southampton, Southampton, England32University of Oxford, Oxford</wicri:cityArea></affiliation></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Welin, Lennart" sort="Welin, Lennart" uniqKey="Welin L" first="Lennart" last="Welin">Lennart Welin</name><affiliation wicri:level="1"><nlm:affiliation>Lidköping Hospital, Lidköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lidköping Hospital, Lidköping</wicri:regionArea><wicri:noRegion>Lidköping</wicri:noRegion></affiliation></author><author><name sortKey="Roussel, Ronan" sort="Roussel, Ronan" uniqKey="Roussel R" first="Ronan" last="Roussel">Ronan Roussel</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre de Recherche des Cordeliers, Paris, France36Université Paris Diderot, Paris, France37Diabétologie, AP-HP, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre de Recherche des Cordeliers, Paris, France36Université Paris Diderot, Paris, France37Diabétologie, AP-HP, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><affiliation wicri:level="2"><nlm:affiliation>Harvard School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sato, Shinichi" sort="Sato, Shinichi" uniqKey="Sato S" first="Shinichi" last="Sato">Shinichi Sato</name><affiliation wicri:level="1"><nlm:affiliation>Osaka Medical Center for Health Science and Promotion/Chiba Prefectural Institute of Public Health, Suita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka Medical Center for Health Science and Promotion/Chiba Prefectural Institute of Public Health, Suita</wicri:regionArea><wicri:noRegion>Suita</wicri:noRegion></affiliation></author><author><name sortKey="Davidson, Karina W" sort="Davidson, Karina W" uniqKey="Davidson K" first="Karina W" last="Davidson">Karina W. Davidson</name><affiliation wicri:level="2"><nlm:affiliation>Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Howard, Barbara V" sort="Howard, Barbara V" uniqKey="Howard B" first="Barbara V" last="Howard">Barbara V. Howard</name><affiliation wicri:level="2"><nlm:affiliation>MedStar Health Research Institute, Hyattsville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>MedStar Health Research Institute, Hyattsville</wicri:cityArea></affiliation></author><author><name sortKey="Leening, Maarten J G" sort="Leening, Maarten J G" uniqKey="Leening M" first="Maarten J G" last="Leening">Maarten J G. Leening</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Leening, Maarten" sort="Leening, Maarten" uniqKey="Leening M" first="Maarten" last="Leening">Maarten Leening</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rosengren, Annika" sort="Rosengren, Annika" uniqKey="Rosengren A" first="Annika" last="Rosengren">Annika Rosengren</name><affiliation wicri:level="1"><nlm:affiliation>Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Greifswald, Greifswald, Germany44DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Greifswald, Greifswald, Germany44DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald</wicri:regionArea><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion><wicri:noRegion>Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Deeg, Dorly J H" sort="Deeg, Dorly J H" uniqKey="Deeg D" first="Dorly J H" last="Deeg">Dorly J H. Deeg</name><affiliation wicri:level="3"><nlm:affiliation>Vrije Universiteit Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Vrije Universiteit Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Stehouwer, Coen D A" sort="Stehouwer, Coen D A" uniqKey="Stehouwer C" first="Coen D A" last="Stehouwer">Coen D A. Stehouwer</name><affiliation wicri:level="1"><nlm:affiliation>Maastricht University Medical Centre, Maastricht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht University Medical Centre, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Giampaoli, Simona" sort="Giampaoli, Simona" uniqKey="Giampaoli S" first="Simona" last="Giampaoli">Simona Giampaoli</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Donfrancesco, Chiara" sort="Donfrancesco, Chiara" uniqKey="Donfrancesco C" first="Chiara" last="Donfrancesco">Chiara Donfrancesco</name><affiliation wicri:level="3"><nlm:affiliation>Istituto Superiore di Sanità, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Kromhout, Daan" sort="Kromhout, Daan" uniqKey="Kromhout D" first="Daan" last="Kromhout">Daan Kromhout</name><affiliation wicri:level="4"><nlm:affiliation>Wageningen University, Wageningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation wicri:level="2"><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany52German Research Center for Cardiovascular Research (DZHK eV), Partner-Site Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany52German Research Center for Cardiovascular Research (DZHK eV), Partner-Site Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Meade, Tom W" sort="Meade, Tom W" uniqKey="Meade T" first="Tom W" last="Meade">Tom W. Meade</name><affiliation wicri:level="2"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>London School of Hygiene and Tropical Medicine, London</wicri:cityArea></affiliation></author><author><name sortKey="Casiglia, Edoardo" sort="Casiglia, Edoardo" uniqKey="Casiglia E" first="Edoardo" last="Casiglia">Edoardo Casiglia</name><affiliation wicri:level="1"><nlm:affiliation>University of Padova, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Padova, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><affiliation wicri:level="2"><nlm:affiliation>University of Bristol, Bristol, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Bristol, Bristol</wicri:cityArea></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="2"><nlm:affiliation>Cardiff University, Cardiff, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Cardiff University, Cardiff</wicri:cityArea></affiliation></author><author><name sortKey="Nagel, Dorothea" sort="Nagel, Dorothea" uniqKey="Nagel D" first="Dorothea" last="Nagel">Dorothea Nagel</name><affiliation wicri:level="3"><nlm:affiliation>Klinikum der Universität München LMU, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum der Universität München LMU, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Assmann, Gerd" sort="Assmann, Gerd" uniqKey="Assmann G" first="Gerd" last="Assmann">Gerd Assmann</name><affiliation wicri:level="1"><nlm:affiliation>Assmann-Stiftung für Prävention, Munster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Assmann-Stiftung für Prävention, Munster</wicri:regionArea><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion></affiliation></author><author><name sortKey="Dagenais, Gilles R" sort="Dagenais, Gilles R" uniqKey="Dagenais G" first="Gilles R" last="Dagenais">Gilles R. Dagenais</name><affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire de Cardiologie et Pneumologie de Québec, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut Universitaire de Cardiologie et Pneumologie de Québec, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sundstrom, Johan" sort="Sundstrom, Johan" uniqKey="Sundstrom J" first="Johan" last="Sundström">Johan Sundström</name><affiliation wicri:level="4"><nlm:affiliation>Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name><affiliation wicri:level="2"><nlm:affiliation>University College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="2"><nlm:affiliation>Medical Research Council Epidemiology Unit, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Medical Research Council Epidemiology Unit, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Whitsel, Eric A" sort="Whitsel, Eric A" uniqKey="Whitsel E" first="Eric A" last="Whitsel">Eric A. Whitsel</name><affiliation><nlm:affiliation>Department of Medicine, University of North Carolina, Chapel Hill65Department of Epidemiology, University of North Carolina, Chapel Hill.</nlm:affiliation><wicri:noCountry code="subField">Chapel Hill</wicri:noCountry></affiliation></author><author><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><affiliation wicri:level="1"><nlm:affiliation>University of Tromsø, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Tromsø, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Hedblad, Bo" sort="Hedblad, Bo" uniqKey="Hedblad B" first="Bo" last="Hedblad">Bo Hedblad</name><affiliation wicri:level="1"><nlm:affiliation>Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name><affiliation wicri:level="2"><nlm:affiliation>Albert Einstein College of Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Albert Einstein College of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Engstrom, Gunnar" sort="Engstrom, Gunnar" uniqKey="Engstrom G" first="Gunnar" last="Engström">Gunnar Engström</name><affiliation wicri:level="1"><nlm:affiliation>Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Rosamond, Wayne D" sort="Rosamond, Wayne D" uniqKey="Rosamond W" first="Wayne D" last="Rosamond">Wayne D. Rosamond</name><affiliation><nlm:affiliation>University of North Carolina, Chapel Hill.</nlm:affiliation><wicri:noCountry code="subField">Chapel Hill</wicri:noCountry></affiliation></author><author><name sortKey="Selvin, Elizabeth" sort="Selvin, Elizabeth" uniqKey="Selvin E" first="Elizabeth" last="Selvin">Elizabeth Selvin</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="2"><nlm:affiliation>University of Glasgow, Glasgow, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>University of Glasgow, Glasgow</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Simon G" sort="Thompson, Simon G" uniqKey="Thompson S" first="Simon G" last="Thompson">Simon G. Thompson</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation wicri:level="2"><nlm:affiliation>University of Cambridge, Cambridge, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University of Cambridge, Cambridge</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Comorbidity</term><term>Diabetes Mellitus (epidemiology)</term><term>Female</term><term>Humans</term><term>Life Expectancy</term><term>Male</term><term>Middle Aged</term><term>Mortality</term><term>Myocardial Infarction (epidemiology)</term><term>Risk Factors</term><term>Stroke (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (épidémiologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Diabète (épidémiologie)</term><term>Espérance de vie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Infarctus du myocarde (épidémiologie)</term><term>Mortalité</term><term>Mâle</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus</term><term>Myocardial Infarction</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Diabète</term><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Life Expectancy</term><term>Male</term><term>Middle Aged</term><term>Mortality</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Espérance de vie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mortalité</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The prevalence of cardiometabolic multimorbidity is increasing.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>Finlande</li><li>France</li><li>Italie</li><li>Japon</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>Turquie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Columbia</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Groningue (province)</li><li>Gueldre (province)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Iowa</li><li>Latium</li><li>Maryland</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Galles du Sud</li><li>Oregon</li><li>Pennsylvanie</li><li>Svealand</li><li>Utrecht (province)</li><li>Washington (État)</li><li>Écosse</li><li>État de New York</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Copenhague</li><li>Groningue</li><li>Heidelberg</li><li>Iowa City</li><li>Leyde</li><li>Lille</li><li>Munich</li><li>Oslo</li><li>Paris</li><li>Rome</li><li>Rotterdam</li><li>Seattle</li><li>Sydney</li><li>Uppsala</li><li>Utrecht</li><li>Wageningue</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Sydney</li><li>Université de Wageningue</li><li>Université de Washington</li><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Barrett Connor, Elizabeth" sort="Barrett Connor, Elizabeth" uniqKey="Barrett Connor E" first="Elizabeth" last="Barrett-Connor">Elizabeth Barrett-Connor</name><name sortKey="Kauhanen, Jussi" sort="Kauhanen, Jussi" uniqKey="Kauhanen J" first="Jussi" last="Kauhanen">Jussi Kauhanen</name><name sortKey="Knuiman, Matthew W" sort="Knuiman, Matthew W" uniqKey="Knuiman M" first="Matthew W" last="Knuiman">Matthew W. Knuiman</name><name sortKey="Nietert, Paul J" sort="Nietert, Paul J" uniqKey="Nietert P" first="Paul J" last="Nietert">Paul J. Nietert</name><name sortKey="Rodriguez, Beatriz" sort="Rodriguez, Beatriz" uniqKey="Rodriguez B" first="Beatriz" last="Rodriguez">Beatriz Rodriguez</name><name sortKey="Rosamond, Wayne D" sort="Rosamond, Wayne D" uniqKey="Rosamond W" first="Wayne D" last="Rosamond">Wayne D. Rosamond</name><name sortKey="Whitsel, Eric A" sort="Whitsel, Eric A" uniqKey="Whitsel E" first="Eric A" last="Whitsel">Eric A. Whitsel</name><name sortKey="Yeap, Bu B" sort="Yeap, Bu B" uniqKey="Yeap B" first="Bu B" last="Yeap">Bu B. Yeap</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Di Angelantonio, Emanuele" sort="Di Angelantonio, Emanuele" uniqKey="Di Angelantonio E" first="Emanuele" last="Di Angelantonio">Emanuele Di Angelantonio</name></region><name sortKey="Bansal, Narinder" sort="Bansal, Narinder" uniqKey="Bansal N" first="Narinder" last="Bansal">Narinder Bansal</name><name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name><name sortKey="Burgess, Stephen" sort="Burgess, Stephen" uniqKey="Burgess S" first="Stephen" last="Burgess">Stephen Burgess</name><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S" last="Butterworth">Adam S. Butterworth</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><name sortKey="Freitag, Daniel F" sort="Freitag, Daniel F" uniqKey="Freitag D" first="Daniel F" last="Freitag">Daniel F. Freitag</name><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><name sortKey="Gao, Pei" sort="Gao, Pei" uniqKey="Gao P" first="Pei" last="Gao">Pei Gao</name><name sortKey="Hart, Carole L" sort="Hart, Carole L" uniqKey="Hart C" first="Carole L" last="Hart">Carole L. Hart</name><name sortKey="Kaptoge, Stephen" sort="Kaptoge, Stephen" uniqKey="Kaptoge S" first="Stephen" last="Kaptoge">Stephen Kaptoge</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name><name sortKey="Meade, Tom W" sort="Meade, Tom W" uniqKey="Meade T" first="Tom W" last="Meade">Tom W. Meade</name><name sortKey="O Keeffe, Linda M" sort="O Keeffe, Linda M" uniqKey="O Keeffe L" first="Linda M" last="O'Keeffe">Linda M. O'Keeffe</name><name sortKey="Pennells, Lisa" sort="Pennells, Lisa" uniqKey="Pennells L" first="Lisa" last="Pennells">Lisa Pennells</name><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><name sortKey="Thompson, Simon G" sort="Thompson, Simon G" uniqKey="Thompson S" first="Simon G" last="Thompson">Simon G. Thompson</name><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><name sortKey="Willeit, Peter" sort="Willeit, Peter" uniqKey="Willeit P" first="Peter" last="Willeit">Peter Willeit</name><name sortKey="Wood, Angela M" sort="Wood, Angela M" uniqKey="Wood A" first="Angela M" last="Wood">Angela M. Wood</name><name sortKey="Wormser, David" sort="Wormser, David" uniqKey="Wormser D" first="David" last="Wormser">David Wormser</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Peters, Sanne A" sort="Peters, Sanne A" uniqKey="Peters S" first="Sanne A" last="Peters">Sanne A. Peters</name></region><name sortKey="Deeg, Dorly J H" sort="Deeg, Dorly J H" uniqKey="Deeg D" first="Dorly J H" last="Deeg">Dorly J H. Deeg</name><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><name sortKey="Kromhout, Daan" sort="Kromhout, Daan" uniqKey="Kromhout D" first="Daan" last="Kromhout">Daan Kromhout</name><name sortKey="Leening, Maarten" sort="Leening, Maarten" uniqKey="Leening M" first="Maarten" last="Leening">Maarten Leening</name><name sortKey="Leening, Maarten J G" sort="Leening, Maarten J G" uniqKey="Leening M" first="Maarten J G" last="Leening">Maarten J G. Leening</name><name sortKey="Stehouwer, Coen D A" sort="Stehouwer, Coen D A" uniqKey="Stehouwer C" first="Coen D A" last="Stehouwer">Coen D A. Stehouwer</name><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="H Heim, Lise Lund" sort="H Heim, Lise Lund" uniqKey="H Heim L" first="Lise Lund" last="H Heim">Lise Lund H Heim</name></region><name sortKey="Nj Lstad, Inger" sort="Nj Lstad, Inger" uniqKey="Nj Lstad I" first="Inger" last="Nj Lstad">Inger Nj Lstad</name><name sortKey="Selmer, Randi" sort="Selmer, Randi" uniqKey="Selmer R" first="Randi" last="Selmer">Randi Selmer</name></country><country name="États-Unis"><region name="District de Columbia"><name sortKey="Gillum, Richard F" sort="Gillum, Richard F" uniqKey="Gillum R" first="Richard F" last="Gillum">Richard F. Gillum</name></region><name sortKey="Crespo, Carlos J" sort="Crespo, Carlos J" uniqKey="Crespo C" first="Carlos J" last="Crespo">Carlos J. Crespo</name><name sortKey="D Agostino, Ralph B" sort="D Agostino, Ralph B" uniqKey="D Agostino R" first="Ralph B" last="D'Agostino">Ralph B. D'Agostino</name><name sortKey="Davidson, Karina W" sort="Davidson, Karina W" uniqKey="Davidson K" first="Karina W" last="Davidson">Karina W. Davidson</name><name sortKey="Howard, Barbara V" sort="Howard, Barbara V" uniqKey="Howard B" first="Barbara V" last="Howard">Barbara V. Howard</name><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B" last="Hu">Frank B. Hu</name><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><name sortKey="Selvin, Elizabeth" sort="Selvin, Elizabeth" uniqKey="Selvin E" first="Elizabeth" last="Selvin">Elizabeth Selvin</name><name sortKey="Trevisan, Maurizio" sort="Trevisan, Maurizio" uniqKey="Trevisan M" first="Maurizio" last="Trevisan">Maurizio Trevisan</name><name sortKey="Wallace, Robert B" sort="Wallace, Robert B" uniqKey="Wallace R" first="Robert B" last="Wallace">Robert B. Wallace</name><name sortKey="Wassertheil Smoller, Sylvia" sort="Wassertheil Smoller, Sylvia" uniqKey="Wassertheil Smoller S" first="Sylvia" last="Wassertheil-Smoller">Sylvia Wassertheil-Smoller</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name></region></country><country name="Finlande"><noRegion><name sortKey="Salonen, Jukka T" sort="Salonen, Jukka T" uniqKey="Salonen J" first="Jukka T" last="Salonen">Jukka T. Salonen</name></noRegion><name sortKey="Nissinen, Aulikki" sort="Nissinen, Aulikki" uniqKey="Nissinen A" first="Aulikki" last="Nissinen">Aulikki Nissinen</name><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name></country><country name="Australie"><noRegion><name sortKey="Simons, Leon A" sort="Simons, Leon A" uniqKey="Simons L" first="Leon A" last="Simons">Leon A. Simons</name></noRegion><name sortKey="Barr, Elizabeth L M" sort="Barr, Elizabeth L M" uniqKey="Barr E" first="Elizabeth L M" last="Barr">Elizabeth L M. 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